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KMID : 1123920020160061236
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 6 p.1236 ~ p.1242
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Improving Effects of Chimae-eum on Learning and Memory Function in the Hippocampal Damaged Rat
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Chi Gyoo-Yong
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Abstract
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In order to make an efficient prescription and cope with dementia, learning and memory functions of Sprague-Dawley model rats were tested with Morris water maze. And to evaluate the effect of the sample drug(CHM) on choline acetyltranferase and acetylcholine esterase, immunoreactive measurement and enzymatic activity measuring were carried out. Rats were injected with ibotenic acid through hippocampus CA1 and CA3 area. The results are as following. CHM improves the learning ability in the acquisition test and memory function in the retention test significantly. And CHM increases the level of AChE which is resolving acetylcholine. Though it doesn’t increase the level of ChAT significantly which is synthesizing acetylcholine, but it shows the tendency of increase. So these results show that CHM improve the cholinergic catabolism and anabolism, and the increment of metabolic activity of cholinergic system. Thus it can be concluded that CHM will be helpful to cholinergic brain disease induced by primary or senile reduction of acetylcholine secretive activity.
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KEYWORD
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Dementia, learning, memory, choline acetyltranferase, acetylcholine esterase, chimae-eum
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